There’s Sarah Biffin, painter born without arms or legs:
Virginia Hall, WW2 spy with a wooden leg:
Amanirenas, one-eyed conqueror of Rome:
Sophie Morigeau, one-eyed Metis frontierswoman who amputated her own rib:
Annie Jump Cannon, deaf astronomer:
Also plenty of folk I’ve covered on the Modern Worthies section of the site.