Martine Rothblatt founded United Therapeutics, the company which she now heads as CEO, and earned a PhD in bioethics in order to create a treatment for her terminally ill daughter, and others like her.
In the 60s, this pioneering businesswoman fought - and won - endless battles to carve out a living for her 300+ female programmer employees.
For decades, the world's best leprosy treatment was the work of an unknown black chemist - whose work was stolen by her successor.
A lack of a college degree and a child born out of wedlock couldn't stop this woman from saving the US Space Race with her custom rocket fuel.
She performed the experiment that overturned the law of conservation of parity and helped lead to the Standard Model of particle physics, while two men got the Nobel Prize for it.
After being refused the opportunity to defend her doctoral thesis due to Nazi anti-Semitism, she returned to it 77 years later.
When jailed for being a political dissident, Lin Zhao continued to write anti-Mao screeds using hairpins, bamboo, and her own blood as ink.
Instead of waiting for politicians to bring down the much-maligned Confederate flag flying nearby the South Carolina capitol building, Bree Newsome got some climbing equipment and did it herself.
An American soldier found and kept the diary of this North Vietnamese civilian doctor for 35 years after her death. When it was finally released to the world, nobody could have guessed the reaction.